papers

     
2024 73. Kabfleisch T=, McKay S=, Murdoch B=, Adelson D, Almansa D, Becker G, Beckett L, Benítez-Galeano M, Biase F, Casey T, Chuong E, Clark E, Clarke S, Cockett N, Couldrey C, Davis B, Elsik C, Faraut T, Gao Y, Genet C, Grady P, Green J, Green R, Guan D, Hagen D, Hartley G, Heaton M, Hoyt S, Huang W, Jarvis E, Kalleberg J, Khatib H, Koepfli K, Koltes J, Koren S, Kühn C, Leeb T, Leonard A, Liu G, Low W, McConnell H, McRae K, Miga K, Mousel M, Neibergs H, Olagunju T, Pennell M, Petry B, Pewsner M, Phillippy A, Pickett B, Pineda P, Potapova T, Rachagani S, Rhie A, Rijnkels M, Robic A, Osorio N, Safonova Y, Schettini G, Schnabel R, Natesh N, Stegemiller M, Storer J, Stothard P, Stull C, Tosser-Klopp G, Traglia G, Tuggle C, Van Tassell C, Watson C, Weikard R, Wimmers K, Xie S, Yang L, Smith T, O’Neill R, Rosen, B (2024) The Ruminant Telomere-to-Telomere (RT2T) Consortium. Nat Genet 56(8):1566-1573
  72. Yamamoto A, Huang W, Carbone MA, Anholt RRH, Mackay TFC (2024) The genetic basis of incipient sexual isolation in Drosophila melanogaster. Proc. R. Soc. B 291:20240672
  71. Quan J=, Yang M=, Cai G=, Ding R, Zhuang Z, Zhou S, Tan S, Ruan D, Wu J, Zheng E, Zhang Z, Liu L, Meng F, Wu J, Xu C, Qiu Y, Wang S, Lin M, Li S, Ye Y, Zhou F, Lin D, Li X, Deng S, Zhang Y, Yao Z, Gao X, Yang Y, Liu Y, Zhan Y, Liu Z, Zhang J, Ma F, Yang J, Chen Q, Yang J, Ye J, Dong L, Gu T, Huang S, Xu Z, Li Z, Yang J, Huang W, Wu Z (2024) Multi-omic characterization of allele-specific regulatory variation in hybrid pigs. Nat Commun 15(1):5587
  70. Yamamoto A, Huang W, Anholt RRH, Mackay TFC (2023) The genetic basis of variation in Drosophila melanogaster mating behavior. iScience 27(5):109837
2023 69. Yin Z, Yang Q, Shen D, Liu J, Huang W, Dou D (2023) Online data resource for exploring transposon insertion polymorphisms in public soybean germplasm accessions. Plant Physiol 193(2):1036-1044
  68. Ding R, Savegnago R, Liu J, Long N, Tan C, Cai G, Zhuang Z, Wu J, Yang M, Qiu Y, Ruan D, Quan J, Zheng E, Hong L, Li Z, Tan S, Bedhane M, Schnabel R, Steibel J, Gondro C, Yang J, Huang W, Wu Z (2023) The SWine IMputation (SWIM) haplotype reference panel enables nucleotide resolution genetic mapping in pigs. Commun Biol 6(1):577
  67. Zhang F, Velez-Irizarry D, Ernst CW, Huang W (2023) Mapping splice QTLs reveals distinct transcriptional and post-transcriptional regulatory variation of gene expression and identifies putative alternative splicing variation mediating complex trait variation in pigs. BMC Genomics 24(1):240
  66. Lyman RF=, Lyman RA=, Yamamoto A=, Huang W=, Harbison ST, Zhou S, Anholt RRH, Mackay TFC (2023) Natural genetic variation in a dopamine receptor is associated with variation in female fertility in Drosophila melanogaster. Proc. R. Soc. B 290:20230375
  65. Liu J, Zhang Y, Zheng Y, Zhu Y, Shi Y, Guan Z, Lang K, Shen D, Huang W, Dou D (2023) PlantExp: a platform for exploration of gene expression and alternative splicing based on public plant RNA-seq samples. Nucleic Acids Res 51(D1):D1483-D1491
2022 64. Liu J, Lang K, Tan S, Jie W, Zhu Y, Huang S, Huang W (2022) A web-based database server using 43,710 public RNA-seq samples for the analysis of gene expression and alternative splicing in livestock animals. BMC Genomics 23(1):706
  63. Ding R=, Zhuang Z=, Qiu Y=, Wang X, Wu J, Zhou S, Ruan D, Xu C, Hong L, Gu T, Zheng E, Cai G, Huang W, Wu Z, Yang J (2022) A composite strategy of genome-wide association study and copy number variation analysis for carcass traits in a Duroc pig population. BMC Genomics 23(1):590
  62. Ding R=, Zhuang Z=, Qiu Y, Ruan D, Wu J, Ye J, Cao L, Zhou S, Zheng E, Huang W, Wu Z, Yang J (2022) Identify known and novel candidate genes associated with backfat thickness in Duroc pigs by large-scale genome-wide association analysis. J Anim Sci 100(2):skac012
  61. Gabrawy M, Khosravian N, Morcos GS, Morozova TV, Jezek M, Walston JD, Huang W, Abadir PM, Leips J (2022) Genome­wide analysis in Drosophila reveals the genetic basis of variation in age­specific physical performance and response to ACE inhibition. Genes 13(1):143
  60. Liu J, Yin F, Lang K, Jie W, Tan S, Duan R, Huang S, Huang W (2022) MetazExp: a database for gene expression and alternative splicing profiles and their analyses based on 53615 public RNA-seq samples in 72 metazoan species. Nucleic Acids Res 50(D1):D1046-D1054
2021 59. Özsoy ED, Yılmaz M, Patlar B, Emecen G, Durmaz E, Magwire MM, Zhou S, Huang W , Anholt RRH, Mackay TFC (2021) Epistasis for head morphology in Drosophila melanogaster. G3 11(10):jakb285
  58. Baker BM, Carbone MA, Huang W, Anholt RRH, Mackay TFC (2021) Genetic basis of variation in cocaine and methamphetamine consumption in outbred populations of Drosophila melanogaster. Proc Natl Acad Sci USA 118(23):e2104131118
2020 57. Morgante F, Huang W, Sørensen P, Maltecca C, Mackay TFC (2020) Leveraging multiple layers of data to predict Drosophila complex traits. G3 10(12):4599-4613
  56. Huang W, Carbone MA, Lyman RF, Anholt RRH, Mackay TFC (2020) Genotype by environment interaction for gene expression in Drosophila melanogaster. Nat Commun 11(1):5451
  55. Chen W, Zhang Z, Chang C, Yang Z, Wang P, Fu H, Wei X, Chen E, Tan S, Huang W, Sun L, Ni T, Yang Y, Wang Y (2020) A bioenergetic shift is required fro spermatogonial differentiation. Cell Discov 6:56
  54. Yanagawa A, Huang W, Yamamoto A, Wada-Katsumata A, Schal C, Mackay TFC (2020) Genetic basis of natural variation in spontaneous grooming in Drosophila melanogaster. G3 10(9): 3453-3460
  53. Zhuang Z, Ding R, Peng L, Wu J, Ye Y, Zhou S, Wang X, Quan J, Zheng E, Cai G, Huang W, Yang J, Wu Z (2020) Genome-wide association analyses identify known and novel loci for teat number in Duroc pigs using single-locus and multi-locus models. BMC Genomics 21(1):344
  52. Everett LJ=, Huang W=, Zhou S, Carbone MA, Lyman RF, Arya GH, Geisz MS, Ma J, Morgante F, St. Armour G, Turlapati L, Anholt RRH, Mackay TFC (2020) Gene expression networks in the Drosophila Genetic Reference Panel. Genome Res 30:485-496
  51. Huang W=, Campbell T=, Carbone MA, Jones WE, Unselt D, Anholt RRH, Mackay TFC (2020) Context-dependent genetic architecture of Drosophila life span. PLoS Biol 18(3):e3000645
  50. Parker GA, Kohn N, Spirina A, McMillen A, Huang W, Mackay TFC (2020) Genetic basis of increased lifespan and postponed senescence in Drosophila melanogaster G3 10(3):1087-1098
  49. Quan J, Wu Z, Ye Y, Peng L, Wu J, Ruan D, Qiu Y, Ding R, Wang X, Zheng E, Cai G, Huang W, Yang J (2020) Metagenomic characterization of intestinal regions in pigs with contrasting feed efficiency. Front Microbiol 11:32
  48. Liu J, Tan S, Huang S, Huang W (2020) ASlive: a database for alternative splicing atlas in livestock animals. BMC Genomics 21(1):97
  47. Matute DR, Comeault AA, Earley E, Serrato-Capuchina A, Peede D, Monroy-Eklund A, Huang W, Jones CD, Mackay TFC, Coyne JA (2020) Rapid and predictable evolution of admixed populations between two Drosophila species pairs. Genetics 214:211-230
  46. Dai Z, Long N, Huang W (2020) Influence of genetic interactions on polygenic prediction. G3 10(1):109-115
2019 45. Ding R, Yang M, Quan J, Li S, Zhuang Z, Zhou S, Zheng E, Hong L, Li Z, Cai G, Huang W, Wu Z, Yang J (2019) Single-locus and multi-locus genome-wide association studies for intramuscular fat in Duroc pigs. Front Genet 10:619
  44. Veturi Y, de Los Campos G, Yi N, Huang W, Vazquez AI, Kühnel B (2019) Modeling heterogeneity in the genetic architecture of ethnically diverse groups using random effect interaction models. Genetics 211(4)1395-1407
  43. Quan J, Cai G, Yang M, Zeng Z, Ding R, Wang X, Zhuang Z, Zhou S, Li S, Yang H, Li Z, Zheng E, Huang W, Yang J, Wu Z (2019) Exploring the fecal microbial composition and metagenomic functional capacities associated with feed efficiency in commercial DLY pigs. Front Microbiol 10:52
  42. Harbison ST, Kumar S, Huang W, McCoy LJ, Smith KR, Mackay TFC (2019) Genome-wide association study of circadian behavior in Drosophila melanogaster. Behav Genet 49(1):60-82
2018 41. Ding R, Yang M, Wang X, Quan J, Zhuang Z, Zhou S, Li S, Xu Z, Zheng E, Cai G, Liu D, Huang W, Yang J, Wu Z (2018) Genetic architecture of feeding behavior and feed efficiency in a Duroc pig population. Front Genet 9:220
  40. Morgante F, Huang W, Maltecca C, Mackay TFC (2018) Effect of genetic architecture on the prediction accuracy of quantitative traits in samples of unrelated individuals. Heredity 120(6):500-514
  39. Mackay TFC, Huang W (2018) Charting the genotype-phenotype map: lessons from the Drosophila melanogaster Genetic Reference Panel. WIRE Dev Biol 7(1):e289
2017 38. Fochler S, Morozova TV, Davis MR, Gearhart AW, Huang W, Mackay TFC, Anholt RRH (2017) Genetics of alcohol consumption in Drosophila melanogaster. Genes Brain Behav 16(7):675-685
  37. Garlapow ME, Everett LJ, Zhou S, Gearhart AW, Fay KA, Huang W, Morozova TV, Arya GH, Turlapati L, St Armour G, Hussain YN, McAdams SE, Fochler S, Mackay TFC (2017) Genetic and genomic response to selection for food consumption in Drosophila melanogaster. Behav Genet 47(2):227-243
2016 36. Huang W, Mackay TFC (2016) The genetic architecture of quantitative traits cannot be inferred from variance component analysis. PLoS Genet 12(11):e1006421
  35. Huang W=, Lyman RF=, Carbone MA, Lyman R, Harbison S, Magwire M, Mackay TFC (2016) Spontaneous mutations and the origin and maintenance of quantitative genetic variation. eLife 5:e14625
  34. Carbone MA, Yamamoto A, Huang W, Lyman RA, Meadors TB, Yamamoto R, Anholt RRH, Mackay TFC (2016) Genetic architecture of natural variation in visual senescence in Drosophila. Proc Natl Acad Sci USA 113(43):E6620-E6629
  33. Hunter CM, Huang W, Mackay TFC, Singh D (2016) The genetic architecture of natural variation in recombination rate in Drosophila melanogaster. PLoS Genet 12(4):e1005951
2015 32. Huang W, Carbone MA, Magwire MM, Peiffer JA, Lyman RF, Stone EA, Anholt RRH, Mackay TFC (2015) Genetic basis of transcriptome diversity in Drosophila melanogaster. Proc Natl Acad Sci USA 112(44):E6010-6019
  31. Morozova TV=, Huang W=, Pray VA, Whitham T, Anholt RRH, Mackay TFC (2015) Polymorphisms in early neurodevelopmental genes affect natural variation in alcohol sensitivity in adult Drosophila. BMC Genomics 16(1):865
  30. Ober U=, Huang W=, Magwire MM, Schlather M, Simianer H, Mackay TFC (2015) Accounting for genetic architecture improves sequence based genomic prediction for a Drosophila fitness trait. PLoS ONE 10(5):e0126880
  29. Dembeck LM, Böröczky K, Huang W, Schal C, Anholt RRH, Mackay TFC (2015) Genetic architecture of natural variation in cuticular hydrocarbon composition in Drosophila melanogaster. eLife 4:e09861
  28. Dembeck LM, Huang W, Carbone MA, Mackay TFC (2015) Genetic basis of natural variation in body pigmentation in Drosophila melanogaster. Fly 9(2):75-81
  27. Carnes MU, Campbell T, Huang W, Butler DG, Carbone MA, Duncan LH, Harbajan SV, King EM, Peterson KR, Weitzel A, Zhou S, Mackay TFC (2015) The genomic basis of postponed senescence in Drosophila melanogaster. PLoS ONE 10(9):e0138569
  26. Garlapow ME, Huang W, Yarboro MT, Peterson KR, Mackay TFC (2015) Quantitative genetics of food intake in Drosophila melanogaster. PLoS ONE 10(9):e0138129
  25. Shorter J, Couch C, Huang W, Carbone, MA, Peiffer J, Anholt RRH, Mackay TFC (2015) Genetic architecture of natural variation in Drosophila melanogaster aggressive behavior. Proc Natl Acad Sci USA 112(27):E3555-3563
  24. Dembeck LM, Huang W, Magwire MM, Lawrence F, Lyman RF, Mackay TFC (2015) Genetic architecture of abdominal pigmentation in Drosophila melanogaster. PLoS Genet 11(5):e1005163
  23. Arya GH, Magwire MM, Huang W, Serrano-Negron YL, Mackay TFC, Anholt RRH (2015) The genetic basis for variation in olfactory behavior in Drosophila melanogaster. Chem Senses 40:233-243
2014 22. Huang W=, Massouras A=, Inoue Y, Peiffer J, Ràmia M, Tarone AM, Turlapati L, Zichner T, Zhu D, Lyman RF, Magwire MM, Blankenburg K, Carbone MA, Chang K, Ellis LL, Fernandez S, Han Y, Highnam G, Hjelmen CE, Jack JR, Javaid M, Jayaseelan J, Kalra D, Lee S, Lewis L, Munidasa M, Ongeri F, Patel S, Perales L, Perez A, Pu L, Rollmann SM, Ruth R, Saada N, Warner C, Williams A, Wu Y, Yamamoto A, Zhang Y, Zhu Y, Anholt RRH, Korbel JO, Mittelman D, Muzny DM, Gibbs RA, Barbadilla A, Johnston JS, Stone EA, Richards S, Deplancke B, Mackay TFC (2014) Natural variation in genome architecture among 205 Drosophila melanogaster Genetic Reference Panel lines. Genome Res 24:1193-1208
  21. Montgomery SL, Vorojeikina D, Huang W, Mackay TFC, Anholt RRH, Rand MD (2014) Genome-wide association analysis of tolerance to methylmercury toxicity in Drosophila implicates myogenic and neuromuscular developmental pathways. PLoS ONE 9(10):e110375
  20. Ellis LL, Huang W, Quinn AM, Ahuja A, Alfreijd B, Gomez FE, Hjelmen CE, Moore KL, Mackay TFC, Johnston JS, Tarone AM (2014) Intrapopulation genome size variation in D. melanogaster reflects life history variation and plasticity. PLoS Genet 10(7):e1004522
2013 19. Swarup S=, Huang W=, Mackay TFC, Anholt RRH (2013) Analysis of natural variation reveals neurogenetic networks for Drosophila olfactory behavior. Proc Natl Acad Sci USA 110(3):1017-1022
  18. Driver A, Huang W, Kropp J, Peñagaricano F, Khatib H (2013) Knockdown of CDKN1C (p57kip2) and PHLDA2 results in developmental changes in bovine pre-implantation embryos. PLoS ONE 8(7):e69490
2012 17. Huang W, Richards S, Carbone MA, Zhu D, Anholt RRH, Ayroles JF, Duncan L, Jordan KW, Lawrence F, Magwire MM, Warner C, Blankenburg K, Han Y, Javaid M, Jayaseelan J, Jhangiani SN, Muzny D, Ongeri F, Perales L, Wu Y-Q, Zhang Y, Zou X, Stone EA, Gibbs RA, Mackay TFC (2012) Epistasis dominates the genetic architecture of Drosophila quantitative traits. Proc Natl Acad Sci USA 109(39):15553-15559
  16. Huang W, Long N, Khatib H (2012) Genome-wide identification and initial characterization of bovine long non-coding RNAs from EST data. Anim Genet 43(6):674-682
  15. Huang W, Nadeem A, Zhang B, Babar M, Soller M, Khatib H (2012) Characterization and comparison of the leukocyte transcriptomes of three cattle breeds. PLoS ONE 7(1):e30244
  14. Huang W, Peñagaricano F, Ahmad KR, Lucey JA, Weigel KA, Khatib H (2012) Association between milk protein gene variants and protein composition traits in dairy cattle. J Dairy Sci 95:440-449
  13. Driver A=, Peñagaricano F=, Huang W, Ahmad K, Hackbart K, Wiltbank M, Khatib H (2012) RNA-Seq analysis uncovers transcriptomic variations between morphologically similar in vivo- and in vitro-derived bovine blastocysts. BMC Genomics 13:118
  12. Wu S, Li C, Huang W, Li W, Li R (2012) Alternative splicing regulated by butyrate in bovine epithelial cells. PLoS ONE 7(6):e39182
2010 11. Huang W, Khatib H (2010) Comparison of transcriptomic landscapes of bovine embryos using RNA-Seq. BMC Genomics 11:711
  10. Huang W, Kirkpatrick BW, Rosa GJM, Khatib H (2010) A genome wide association study using selective DNA pooling identifies candidate markers for fertility in Holstein cattle. Anim Genet 41(6):570-578
  9. Huang W, Yandell BS, Khatib H (2010) Transcriptomic profiling of bovine IVF embryos revealed candidate genes and pathways involved in early embryonic development. BMC Genomics 11:23
  8. Khatib H, Monson RL, Huang W, Khatib R, Schutzkus V, Khateeb H, Parrish JJ (2010) Validation of in vitro fertility genes in a Holstein bull population. J Dairy Sci 93(5):2244-2249
2009 7. Huang W, Mikhail D, Bindrim AC, Khatib H (2009) Interactions of the bovine placental lactogen and prolactin receptor genes are associated with fertility traits in cattle. Animal 3(12):1743-1745
  6. Khatib H, Huang W, Mikhail D, Schutzkus V, Monson RL (2009) Effects of signal transducer and activator of transcription (STAT) genes STAT1 and STAT3 genotypic combinations on fertilization and embryonic survival rates in Holstein cattle. J Dairy Sci 92(12):6186-6191
  5. Wang X, Schutzkus V, Huang W, Rosa GJM, Khatib H (2009) Analysis of segregation distortion and association of the bovine FGF2 with fertilization rate and embryonic survival. Anim Genet 40(5):722-728
  4. Driver AM, Huang W, Gajic S, Monson RL, Rosa GJM, Khatib H (2009) Effects of the progesterone receptor variants on fertility traits in cattle. J Dairy Sci 92(8):4082-4085
  3. Khatib H, Huang W, Wang X, Tran AH, Bindrim AC, Schutzkus V, Monson RL, Yandell BS (2009) Single gene and gene interaction effects on fertilization and embryonic survival rates in cattle. J Dairy Sci 92(5):2238-2247
2008 2. Huang W, Maltecca C, Khatib H (2008) A proline-to-histidine mutation in POU1F1 is associated with production traits in dairy cattle. Anim Genet 39(5):554-557
2006 1. Huang W=, Dong Z=, Wei H, Ding C, Sun R, Tian Z (2006) Selective elimination of hepatic natural killer T cells with Concanavalin A improves liver regeneration in mice. Liver Int 26(3):339-345